Journal
ORGANIC LETTERS
Volume 18, Issue 10, Pages 2387-2390Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.6b00873
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Funding
- Natural Science Foundation of China [21373073]
- Young National Natural Science Foundation of China [21302033]
- PCSIRT [IRT 1231]
- Hangzhou Normal University
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An efficient organocatalytic Michael/aldol/hemiacetalization cascade reaction for construction of enantioenriched spirocyclic oxindoles fused with tetrahydropyrane has been developed. The desired highly functionalized 5',6'-dihydro-2'H,4'H-spiro [indoline-3,3'-pyran]-2-one derivatives containing multiple stereogenic centers were obtained in moderate to high chemical yields and with high stereo-selectivities.
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