Journal
ORGANIC LETTERS
Volume 18, Issue 11, Pages 2708-2711Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.6b01170
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Funding
- National Natural Science Foundation of China [81273397, 81561148011]
- Chinese National Science & Technology Major Project Key New Drug Creation and Manufacturing Program [2013ZX09508104]
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A straightforward and efficient method has been developed for the synthesis of 2-benzylbenzaldehyde derivatives from 2-methylbenzaldehyde and iodobenzene via a C(sp(3))-H activation process. In the course of the activation reaction, acetohydrazone is formed between 2-benzylbenzaldehyde and acetohydrazine as a transient directing group. As a new kind of transient directing group, acetohydrazone exhibits a remarkable directing effect to give corresponding products in good to excellent yields.
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