Journal
ORGANIC LETTERS
Volume 18, Issue 10, Pages 2507-2510Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.6b01162
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Funding
- National Natural Science Foundation of China [21272085, 21472056]
- Central China Normal University [2015YBYB087]
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An unprecedented direct dual C-H bond functionalization of unprotected anilines and methyl ketones has been demonstrated. It is the first example of iodine-promoted highly chemo- and site-selective oxidative C-H/C-H cross-coupling of anilines and methyl ketones to furnish the C4-dicarbonylation of anilines in moderate to good yields. Moreover, coproduct HI acted as a catalyst in the reaction. The salient feature of this approach is unprecedented C-H functionalization rather than N-H functionalization of unprotected anilines.
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