Journal
ORGANIC LETTERS
Volume 18, Issue 24, Pages 6460-6463Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.6b03352
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Funding
- Natural Science Foundation of China [21472039, 21625203]
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A new copper-catalyzed tandem C-H oxidative radical functionalization and annulation of aniline-linked 1,7-enynes with alkyl nitriles or acetone is described. This reaction allows the selective construction of 1H-cyclopenta[c]quinolines and benzo[j]phenanthridin-6(5H)-ones which rely on the substitution effect at the 2-position of the acrylamide moiety. The mechanism involving a 1,5-hydride shift process is proposed according to the control deuterium-labeled experiment.
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