Journal
ORGANIC LETTERS
Volume 18, Issue 13, Pages 3174-3177Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.6b01390
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Funding
- 1000 Youth Talents Plan, Science Foundation for Distinguished Young Scholars of Guangdong Province [2014A030306018]
- National Natural Science Foundation of China [21472052]
- Fundamental Research Funds for the Central Universities [2015PT018]
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A new benzylation protocol, enabling straightforward access to,beta-benzylated quinolines, has been demonstrated. By employing readily available [RuCl2(p-cymene)](2) as a catalyst and O-2 as a sole green oxidant, various 1,2,3,4-tetrahydroquinolines were efficiently converted in combination with aryl aldehydes into desired products in a step- and atom economic fashion together with the advantages of excellent functional group tolerance and chemoselectivity, offering an important basis for the transformation of saturated N-heterocycles into functionalized N-heteroaromatics via a dehydrogenative cross-coupling strategy. Mechanistic investigations support that the reaction undergoes a monodehydrogenation-triggered beta-benzylation mode.
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