Journal
ORGANIC LETTERS
Volume 18, Issue 14, Pages 3434-3437Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.6b01612
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- GlaxoSmithKline
- EPSRC
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The first Rh-catalyzed C-H amidation of pyridines is reported. The incorporation of a substituent at the C-2 position both is crucial to the success of this transformation and provides considerable scope for further elaboration of the resulting products. Among these compounds, 2-chloropyridines allow access to a selection of intermediates including a versatile azaquinazoline scaffold.
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