Journal
ORGANIC LETTERS
Volume 18, Issue 14, Pages 3338-3341Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.6b01437
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Funding
- German National Academy of Sciences Leopoldina [LPDS 2011-2]
- Daimler Benz foundation
- Villum Kann Rasmussen Foundation [VKR10101]
- Deutsche Forschungsgemeinschaft [SFB 1127]
- ERC
- Villum Fonden [00010101] Funding Source: researchfish
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Based on fungus fungus pairing assays and HRMS-based dereplication strategy, six new cyclic tetrapeptides, pseudoxylallemycins A-F (1-6), were isolated from the termite-associated fungus Pseudoxylaria sp. X802. Structures were characterized using NMR. spectroscopy, HRMS, and Marfey's reaction. Pseudoxylallemycins B-D (2-4) possess a rare and chemically accessible allene moiety amenable for synthetic modifications, and derivatives A-D showed antimicrobial activity against Gram-negative human-pathogenic Pseudomonas aeruginosa and antiproliferative activity against human umbilical vein endothelial cells and K-562 cell lines.
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