Journal
ORGANIC LETTERS
Volume 18, Issue 9, Pages 2292-2295Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.6b00939
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Funding
- CNRS
- MRES
- UPMC
- ANR [ANR-12-BS07-0031-01COCACLIGHT]
- CarBioRed [ANR-12-BS07-0024]
- Agence Nationale de la Recherche (ANR) [ANR-12-BS07-0031, ANR-12-BS07-0024] Funding Source: Agence Nationale de la Recherche (ANR)
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Herein an extremely versatile, well-defined, low-valent cobalt catalyst [Co(PMe3)(4)] capable of intermolecular and intramolecular imine-directed C2-alkylation and alkenylation of indoles is reported. The reaction proceeds in the absence of reducing agents or additives, affording a range of substituted indoles and dihydropyrroloindoles in high yields and regioselectivities. With the aid of deuterium labeling studies and DFT (Density Functional Theory) calculations, a mechanism is proposed that is based on a Ligand-to-Ligand Hydrogen Transfer pathway.
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