Journal
ORGANIC LETTERS
Volume 18, Issue 15, Pages 3638-3641Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.6b01684
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- CSIR [BSC 0108]
- UGC
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We present a metal-free method for the synthesis of imides by the direct coupling of NH-amides with methylarenes under iodine/aqueous TBHP conditions. The optimized conditions worked very well with benzaldehydes and benzyl alcohol and furnished the corresponding imides in good to excellent yields. A series of control and radical scavenger experiments were also performed, which suggested the involvement of radical pathways. The labeling experiment in the presence of O-18-labeled H2O suggested water as a source of oxygen in the imides.
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