Journal
ORGANIC LETTERS
Volume 18, Issue 24, Pages 6452-6455Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.6b03347
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- Nanyang Technological University
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Reaction of potassium aryloxymethyltrifluoroborates 1 with alpha,beta-unsaturated carbonyl compounds 2 in the presence of a chiral diene-rhodium catalyst in H2O at 100 degrees C introduced 2-methoxyaryl groups at the beta-position of 2 with high enantioselectivity in high yields. The reaction is assumed to proceed through 1,4-Rh shift from aryloxymethyl-Rh intermediate to 2-methoxyaryl-Rh. The high availability of phenol derivatives makes this asymmetric conjugate arylation synthetically useful.
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