Journal
ORGANIC LETTERS
Volume 18, Issue 21, Pages 5584-5587Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.6b02818
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Funding
- National Science and Technology Major Projects of China [2014ZX10005002-005]
- National Natural Science Foundation of China [81502949]
- Natural Science Foundation of Guangdong Province [2015A030310482, 2016A030313149]
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A general and excellent acylation reagent, diacyl disulfide, was uncovered for efficient ester formation enabled by DMAP (4-(N,N-dimethylamino)pyridine) catalysis. This protocol offered a promising synthetic platform on site-selective acylation of phenolic and primary aliphatic hydroxyl groups, which greatly expanded the realm of protecting group chemistry. The importance of the reagent was also reflected by its excellent moisture tolerance, high efficiency, and potential in synthetic chemistry and biologically meaningful natural product modification.
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