Journal
ORGANIC LETTERS
Volume 18, Issue 13, Pages 3222-3225Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.6b01466
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Funding
- SNSF [PP00P2_157607]
- Kanton of Zurich
- Swiss National Science Foundation [310030_157019]
- Swiss National Science Foundation (SNF) [310030_157019] Funding Source: Swiss National Science Foundation (SNF)
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A methodology for the synthesis of oligophosphate conjugates using phosphordiamidites is described. This strategy facilitates the straightforward preparation of C-2-symmetric dinucleoside tri-, penta-, and heptaphosphates. Moreover, unsymmetric compounds such as thiamine adenosine triphosphate and thiamine cytidine triphosphate can be prepared. The material is used to study the inhibitory activity of thiaminylated nucleotides against adenosine diphosphate ribosyltransferases.
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