4.8 Article

Copper-Catalyzed Direct Propargylation of Polyfluoroarenes with Secondary Propargyl Phosphates

Journal

ORGANIC LETTERS
Volume 18, Issue 13, Pages 3302-3305

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.6b01642

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Funding

  1. National Basic Research Program of China (973 Program) [2015CB931900]
  2. National Natural Science Foundation of China [21425208, 21421002, 21332010]
  3. Strategic Priority Research Program of the Chinese Academy of Sciences [XDB20020000]
  4. SIOC

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A copper-catalyzed direct propargylation of polyfluoroarenes with secondary propargyl phosphates has been developed. The reaction proceeds under mild reaction conditions with high efficiency and regioselectivity and provides a concise and straightforward method for the synthesis of polyfluoroarylated derivatives of interest in both life and materials science.

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