Journal
ORGANIC LETTERS
Volume 18, Issue 9, Pages 2196-2199Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.6b00806
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Funding
- National Natural Science Foundation of China [21372187, 21572194, 21502160]
- Program for Innovative Research Cultivation Team in University of Ministry of Education of China [1337304]
- Hunan Provincial Innovative Foundation for Postgraduate [CX2015B202]
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A novel route is disclosed for the synthesis of 1,2,4-thiadiazoles starting from amidines, elemental sulfur, and 2-methylquinolines or aldehydes under transition-metal-free conditions. This three-component approach affords efficient and rapid access to 3,5-diaryl substituted 1,2,4-thiadiazoles with good tolerance of a broad range of funcitional groups. Mechanistic studies reveal a radical-involved pathway.
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