4.8 Article

Copper-Catalyzed Aza-Diels-Alder Reaction and Halogenation: An Approach To Synthesize 7-Halogenated Chromenoquinolines

Journal

ORGANIC LETTERS
Volume 18, Issue 10, Pages 2491-2494

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.6b01065

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Funding

  1. National Natural Science Foundation of China [21273026, 21572028]
  2. Fundamental Research Funds for the Central Universities [DUT15LK37]
  3. Outstanding Young Scholars Development Growth Plan of universities in Liaoning Province [LJQ2015027]

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A new halogenation method to construct halogen-substituted quinoline moieties is described. The Cu-catalyzed intramolecular aza-Diels-Alder reaction and halogenation reaction proceeded smoothly under mild conditions to produce the corresponding 7-chloro-6H-chromeno[4,3-b]quinolines and 7-chloro-6H-thiochromend[4,3-b]quinolines in satisfactory yields.

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