Synthesis of Alkaloid-Mimicking Tricyclic Skeletons by Diastereo- and Regioselective Ugi/ipso-Cyclization/Aza-Michael Cascade Reaction in One-Pot

A one-pot process has been developed for preparing alkaloid-like tricyclic skeletons by employing an Ugi reaction, an acid mediated ipso-cyclization and an aza-Michael addition. The transformation is operationally simple and provides products in a diastereo- and regioselective manner with good-to-excellent yields.