4.8 Article

Total Synthesis of (+)-Vicenin-2

Journal

ORGANIC LETTERS
Volume 18, Issue 18, Pages 4488-4490

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.6b02203

Keywords

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Funding

  1. JSPS KAKENHI [JP23000006, JP16H06351, JP16H01137, JP16H04107]
  2. Grants-in-Aid for Scientific Research [16H01137, 16H04107] Funding Source: KAKEN

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The bis-C-glucosyl flavonoid vicenin-2 (1) has been synthesized by exploiting bis-C-glycosylation of 1,3,5-trifluorobenzene and aromatic nucleophilic substitution to transform fluorine atoms to oxygen functions in excellent yield.

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