4.8 Article

Formal Total Synthesis of (±)-Strictamine Based on a Gold-Catalyzed Cyclization

Journal

ORGANIC LETTERS
Volume 18, Issue 7, Pages 1670-1673

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.6b00536

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Funding

  1. Japan Society for the Promotion of Science (JSPS)
  2. MEXT, Japan
  3. Grants-in-Aid for Scientific Research [15H04654, 24689001, 15KT0061] Funding Source: KAKEN

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A gold-catalyzed cyclization of 1-propargyl-1,2,3,4-tetrahydro-beta-carboline led to formation the D-ring of strictamine. Functional group modifications of the resulting tetracyclic indolenine led to the formal total synthesis of (+/-)-strictamine.

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