Journal
ORGANIC LETTERS
Volume 18, Issue 14, Pages 3474-3477Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.6b01672
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- Excellence Cluster Center of Integrated Protein Science Munich (CIPSM)
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An operationally simple one-pot reaction for the preparation of a novel class of racemic trifluoromethylated 2,3dihydro-1H-imidazoles derived from electron-poor N,O-acetals and aryl Grignard reagents is described. In addition, access to highly functionalized 2-trifluoromethyl-2,3-dihydro-1H-imidazoles was accomplished by reaction of N-aryl hemiaminal ethers and N-aryl trifluoroethylamines in the presence of an excess of n-butyllithium.
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