Journal
ORGANIC LETTERS
Volume 18, Issue 5, Pages 1096-1099Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.6b00169
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Funding
- University of Pennsylvania
- National Science Foundation
- National Institutes of Health [NIH RR-023/11, CHE-0840438]
- Kwanjeong Educational Foundation
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Triptycenes have been shown to bind nucleic acid three-way junctions, but rapid and efficient methods to diversify the triptycene core are lacking. An efficient synthesis of a 9-substituted triptycene scaffold is reported that can be used as a building block for solid-phase peptide synthesis and rapid diversification. The triptycene building block was diversified to produce a new class of tripeptide triptycenes, and their binding abilities toward d(CAG)center dot(CTG) repeat junctions were investigated.
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