Journal
ORGANIC LETTERS
Volume 18, Issue 4, Pages 642-645Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.5b03499
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Funding
- MINECO (Spain) [CTQ2011-28258, CTQ2014-59015R]
- Xunta de Galicia [GRC2014/032]
- European Regional Development Fund [CTQ2014-59015R, GRC2014/032]
- MEC
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A novel route to 1,3-oxazaheterocycles based on cooperative RuH/Bronsted acid catalysis is reported. The use of the commercially available RuH2(CO)(PPh3)(3) complex allows for an efficient long distance chain-walking process while the Bronsted acid is responsible for generation of an electrophilic iminium ion which is trapped intramolecularly by an alcohol moiety. The alcohol, besides its nucleophilic function, also plays an important role in the stabilization of the Ru catalyst.
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