Journal
ORGANIC LETTERS
Volume 18, Issue 3, Pages 576-579Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.5b03615
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Funding
- Thousand Plan Youth program
- Bayer Investigator Fellowship
- Tsinghua-Peking centre for life sciences (CLS)
- Tsinghua University
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The first catalytic alpha-fluoroallenoate synthesis is described. With a suitable combination of N-heterocyclic carbene precatalyst, base, and fluorine reagent, the reaction proceeded smoothly to yield a wide range of alpha-fluoroallenoates with excellent chemoselectivity. These substituted alpha-fluorinated allenoates have been synthesized for the first time, and they are versatile synthetic intermediates toward other useful fluorine-containing building blocks.
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