Journal
ORGANIC LETTERS
Volume 18, Issue 22, Pages 5800-5803Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.6b02699
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Funding
- Operational Program Education and Lifelong Learning [PE 2431]
- ESF
- Greek State
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An organocatalytic linchpin catalysis approach was envisaged to convert simple aldehydes into enantioenriched 2-oxopiperazines. A four-step reaction sequence (chlorination, oxidation, substitution, and cyclization) was developed and led to different substitution patterns in high yields and selectivities. The reaction mechanism was studied, and the previously elusive epoxy lactone intermediate was identified by FIRMS.
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