Journal
ORGANIC LETTERS
Volume 18, Issue 10, Pages 2391-2394Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.6b00879
Keywords
-
Categories
Funding
- JST, ACT-C
- KAKENHI from JSPS [25713002]
- Naito Foundation
- Grants-in-Aid for Scientific Research [25713002, 16H01043] Funding Source: KAKEN
Ask authors/readers for more resources
Direct enolate formation coupled with subsequent enantioselective C-C bond formation remains a topic of intense interest in asymmetric catalysis. This methodology is achieved even with low acidic amides without an electron-withdrawing group at the alpha-position in the context of a Mannich-type reaction. Acetate-, propionate-, and butyrate-type 7-azaindoline amides served as enolate precursors to afford the desired Mannich adducts with high stereoselectivity, and ligand-enabled diastereo-divergency provided access to both anti/syn diastereomers. The facile transformation of the amide moiety ensures the synthetic utility of the Mannich adducts.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available