Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 14, Issue 24, Pages 5555-5558Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6ob00290k
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Funding
- University of California, San Diego
- US Army Research Laboratory
- US Army Research Office [W911NF-13-1-0383]
- National Science Foundation [CHE-1254611]
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [1254611] Funding Source: National Science Foundation
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As more methodologies for generating and manipulating biomimetic cellular systems are developed, opportunities arise for combining different methods to create more complex synthetic biological constructs. This necessitates an increasing need for tools to selectively trigger individual methodologies. Here we demonstrate ruthenium tris-bipyridine mediated photoredox triggering of the copper catalyzed alkyne azide cycloaddition reaction (CuAAC), resulting in the synthesis of biomimetic phospholipids in situ, and subsequent membrane assembly. The use of a ruthenium-copper electron transport chain to trigger phospholipid assembly opens up future opportunities for spatiotemporal synthesis of membranes.
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