Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 14, Issue 7, Pages 2291-2296Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5ob02546j
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Funding
- CNPq (INCT-INOFAR) [CNPq 573.564/2008-6, FAPERJ E-26/170.020/2008]
- Cristalia Produtos Quimicos Farmaceuticos
- FAPESP [2012/02230-0]
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A practical and convergent asymmetric route to calcium atorvastatin (1) is reported. The synthesis of calcium atorvastatin (1) was performed using the remote 1,5-anti asymmetric induction in the boron-mediated aldol reaction of beta-alkoxy methylketone (4) with pyrrolic aldehyde (3) as a key step. Calcium atorvastatin was obtained from aldehyde (3) after 6 steps, with a 41% overall yield.
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