Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 14, Issue 36, Pages 8586-8597Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6ob01706a
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Funding
- US NIH [R01HD065122, R01GM076360- 04S1, U01CA199792]
- China Scholarship Council
- NSF [DBIO-722538]
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A facile one-pot two-enzyme chemoenzymatic approach has been established for the gram (Neu4,5Ac(2)alpha 3Lac, 1.33 g) and preparative scale (Neu4,5Ac(2)alpha 3LNnT) synthesis of monotreme milk oligosaccharides. Other O-acetyl-5-N-acetylneuraminic acid (Neu4,5Ac(2))-or 4-O-acetyl-5-N-glycolylneuraminic acid (Neu4Ac5Gc) -containing alpha 2-3-sialosides have also been synthesized in the preparative scale. Used as an effective probe, Neu4,5Ac(2 alpha)3Gal beta rho NP was found to be a suitable substrate by human influenza A viruses but not bacterial sialidases.
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