Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 14, Issue 26, Pages 6165-6178Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6ob01010e
Keywords
-
Categories
Funding
- EPSRC [EP/M01792X/1]
- i-sense EPSRC IRC in Early Warning Sensing Systems for Infectious Diseases [EP/K031953/1]
- EPSRC [EP/K031953/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/K031953/1] Funding Source: researchfish
Ask authors/readers for more resources
With the advent of novel bioorthogonal reactions and click chemistry, an increasing number of strategies for the single labelling of proteins and oligonucleotides have emerged. Whilst several methods exist for the site-selective introduction of a single chemical moiety, site-selective and bioorthogonal dual modification of biomolecules remains a challenge. The introduction of multiple modules enables a plethora of permutations and combinations and can generate a variety of bioconjuguates with many potential applications. From de novo approaches on oligomers to the post-translational functionalisation of proteins, this review will highlight the main strategies to dually modify biomolecules.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available