Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 14, Issue 1, Pages 149-157Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5ob01681a
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Funding
- BBSRC through a Doctoral Training Account (BBSRC-DTA)
- University of Southampton
- EPSRC [EP/I016651/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/I016651/1] Funding Source: researchfish
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Porphyrins were attached to LNA uridine building blocks via rigid 5-acetylene or more flexible propargylamide linkers and incorporated into DNA strands. The systems show a greatly increased thermodynamic stability when using as little as three porphyrins in a zipper arrangement. Thermodynamic analysis reveals clustering of the strands into more ordered duplexes with both greater negative Delta Delta S and Delta Delta H values, and less ordered duplexes with small positive Delta Delta S differences, depending on the combination of linkers used. The exciton coupling between the porphyrins is dependent on the flanking DNA sequence in the single stranded form, and on the nature of the linker between the nucleobase and the porphyrin in the double stranded form; it is, however, also strongly influenced by intermolecular interactions. This system is suitable for the formation of stable helical chromophore arrays with sequence and structure dependent exciton coupling.
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