4.6 Article

Copper-catalyzed enantioselective C-H functionalization of indoles with an axially chiral bipyridine ligand

Journal

ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 14, Issue 35, Pages 8237-8240

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c6ob01516f

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Funding

  1. National Natural Science Foundation of China [21372220, 21532006]
  2. Dalian Institute of Chemical Physics [DMTO201501]

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Using copper complexes with an axially chiral bipyridine ligand C4-ACBP as the catalyst, an enantioselective functionalization of indoles with diazo compounds was developed with up to 95% ee. This protocol paves the way for further applications of these ligands.

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