Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 14, Issue 19, Pages 4534-4541Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6ob00631k
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Funding
- EPSRC (Durham University EPSRC DTG)
- Alberta Innovates Health Solutions Fellowship
- Banting Postdoctoral Fellowship
- Engineering and Physical Sciences Research Council [1213303, 1310966] Funding Source: researchfish
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Herein we report a practical synthetic route to the lasso peptide lassomycin (1) and C-terminal variant lassomycin-amide (2). The biological evaluation of peptides 1 and 2 against Mycobacterium tuberculosis revealed that neither had any activity against this bacterium. This lack of biological activity has led us to propose that naturally occurring lassomycin may actually exhibit a standard lasso peptide threaded conformation rather than the previously reported unthreaded structure.
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