Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 14, Issue 25, Pages 6065-6070Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6ob00768f
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The synthesis of privileged structures, which are potent drug candidates, is an impetus for drug discovery. The construction of heterocyclic framework furo[3,2-c]coumarins using a visible-light promoted photoredox neutral coupling of 3-bromo-4-hydroxycoumarins with commercially available alkynes has been reported. These reactions can be carried out at room temperature under visible light irradiation with good chemical yields. This work presents 17 furocoumarins, 12 of which are new. Three of the newly synthesized compounds show potent cytotoxicity, and one shows moderate acetylcholinesterase inhibitory activity with IC50 values of 2.16 +/- 0.13 mu M.
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