4.6 Article

Synthesis and activity of a novel inhibitor of nonsense-mediated mRNA decay

Journal

ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 14, Issue 5, Pages 1559-1563

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c5ob02482j

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Funding

  1. EPSRC
  2. University of Sheffield
  3. Medical Research Council [MC_PC_12022] Funding Source: researchfish
  4. Cystic Fibrosis Trust [RS33] Funding Source: researchfish
  5. MRC [MC_PC_12022] Funding Source: UKRI

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During efforts to prepare the known compound NMDI1, a new tetracyclic compound, called VG1, was prepared in six steps. This compound was found to have good activity as an inhibitor of non-sense-mediated mRNA decay.

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