Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 14, Issue 40, Pages 9481-9484Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6ob01960a
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- Ministry of Education, Culture, Sports, Science and Technology, MEXT (Japan) [22136006]
- Japan Society for the Promotion of Science (JSPS)
- Takeda Science Foundation
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Three 2'-C,4'-C-ethyleneoxy-bridged 2'-deoxyribonucleic acids possessing six-membered bridges with 6'-oxygen and 8'-exocyclic methylene groups (methylene-EoDNAs) were designed and synthesized in nine to ten steps from 5-methyluridine. The methylene-EoDNA-modified oligonucleotides showed excellent binding affinity with target ssRNA and extremely high nuclease resistance compared with natural oligonucleotides. These results proved the potential of methylene-EoDNAs for nucleic acid based technology.
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