Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 14, Issue 9, Pages 2723-2730Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5ob02622a
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An efficient asymmetric hydrogenation of delta-keto Weinreb amides catalyzed by a Ru-Xyl-SunPhos-Daipen bifunctional catalyst has been achieved. This method afforded a series of enantio-enriched delta-hydroxy Weinreb amides in good yields (up to 93%) and enantioselectivities (up to 99%). This protocol was successfully applied to the synthesis of the key intermediate of (+)-Centrolobine.
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