4.6 Article

Total synthesis of haliclamide

Journal

ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 14, Issue 39, Pages 9287-9293

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c6ob01775d

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Funding

  1. CSIR, New Delhi
  2. Department of Science and Technology, New Delhi [SB/FT/CS-178/2011]

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A stereoselective approach for the synthesis of haliclamide 1, a marine natural product, has been developed. The notable features of our synthesis include MacMillan cross aldol, Mitsunobu inversion, Yamaguchi-Hirao alkylation, Steglich esterification and macrolactamization reactions and the Corey-Fuchs protocol as the key steps.

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