Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 14, Issue 3, Pages 947-956Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5ob02229k
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Funding
- EPSRC-BBSRC-MRC [EP/I037229/1]
- EPSRC
- Saudi Cultural Bureau
- BBSRC [BB/D524140/1]
- SPARC
- ESRC under the New Dynamics of Ageing Initiative [RES-356-25-0024]
- R M Phillips Trust
- Biotechnology and Biological Sciences Research Council [BB/D524140/1] Funding Source: researchfish
- Economic and Social Research Council [ES/G037205/1] Funding Source: researchfish
- Engineering and Physical Sciences Research Council [1224312, EP/I037229/1] Funding Source: researchfish
- EPSRC [EP/I037229/1] Funding Source: UKRI
- ESRC [ES/G037205/1] Funding Source: UKRI
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Microwave-assisted synthesis of the pyrazolyl ketone p38 MAPK inhibitor RO3201195 in 7 steps and 15% overall yield, and the comparison of its effect upon the proliferation of Werner Syndrome cells with a library of pyrazolyl ketones, strengthens the evidence that p38 MAPK inhibition plays a critical role in modulating premature cellular senescence in this progeroid syndrome and the reversal of accelerated ageing observed in vitro on treatment with SB203580.
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