Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 21, Issue 45, Pages 16162-16171Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201502177
Keywords
cancer; drug delivery; fluorescence; imaging agents; nanoparticles
Categories
Funding
- National Natural Science Foundation of China [21573040, 21173038, 21401013, 21301027]
- Natural Science Foundation and Science and Technology Development Planning of Jilin Province [20130522136JH, 20130521010JH, 20140520088JH]
- Program for New Century Excellent Talents in University [NCET-13-0720]
- Specialized Research Fund for the Doctoral Program of Higher Education (New Teachers) [20132216120002]
- National Hi-Technology Research and Development Program (863 Program) [2013AA032204, 2014DFA31740]
- Jilin Provincial Key Laboratory of Micro-Nano Functional Materials (Northeast Normal University)
- Postdoctoral Science Foundation of China [2014M551155]
Ask authors/readers for more resources
We have rationally designed a new theranostic agent by coating near-infrared (NIR) light-absorbing polypyrrole (PPY) with poly(acrylic acid) (PAA), in which PAA acts as a nanoreactor and template, followed by growing small fluorescent silica nanoparticles (fSiO(2) NPs) inside the PAA networks, resulting in the formation of polypyrrole@polyacrylic acid/fluorescent mesoporous silica (PPY@PAA/fmSiO(2)) core-shell NPs. Meanwhile, DOX-loaded PPY@PAA/fmSiO(2) NPs as pH and NIR dual-sensitive drug delivery vehicles were employed for fluorescence imaging and chemo-photothermal synergetic therapy in vitro and in vivo. The results demonstrate that the PPY@PAA/fmSiO(2) NPs show high in vivo tumor uptake by the enhanced permeability and retention (EPR) effect after intravenous injection as revealed by in vivo fluorescence imaging, which is very helpful for visualizing the location of the tumor. Moreover, the obtained NPs inhibit tumor growth (95.6% of tumors were eliminated) because of the combination of chemo-photothermal therapy, which offers a synergistically improved therapeutic outcome compared with the use of either therapy alone. Therefore, the present study provides new insights into developing NIR and pH-stimuli responsive PPY-based multifunctional platform for cancer theranostics.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available