Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 14, Issue 23, Pages 5263-5271Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6ob00725b
Keywords
-
Categories
Funding
- National Institutes of Health
- University of California Cancer Research Coordinating Committee
Ask authors/readers for more resources
Herboxidiene is a potent inhibitor of spliceosomes. It exhibits excellent anticancer activity against multiple human cancer cell lines. Herein, we describe an enantioselective synthesis of a desmethyl derivative and the corresponding carba-derivatives of herboxidiene. The synthesis involved Suzuki coupling of a vinyl iodide with boronate as the key reaction. For the synthesis of carba-derivatives, the corresponding optically active cyclohexane-1,3-dicarbonyl derivatives were synthesized using an enantioselective desymmetrization of meso-anhydride. The biological properties of these derivatives were evaluated in an in vitro splicing assay.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available