Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 14, Issue 38, Pages 9063-9071Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6ob01539e
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- SERB (DST)
- University of Delhi
- CSIR
- UGC
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An efficient step-economical tandem approach for the direct synthesis of pyrido fused indole, quinoline, benzofuran and benzothiophene derivatives using a bimetallic Pd/Cu catalytic system has been described. The three component reaction of o-halo aldehydes, alkynes and tert-butylamine leads to the synthesis of biologically active polyheterocycles. The present strategy involves the dual role of tert-butylamine and copper(I) in Sonogashira coupling followed by electrophilic cyclization through imine formation. The chemistry has been validated by X-ray crystallographic studies.
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