Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 22, Issue 11, Pages 3558-3570Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201503412
Keywords
alcohols; asymmetric amplification; copper; homogeneous catalysis; Grignard reagents
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Funding
- Netherlands Organization for Scientific Research (NWO-Vidi)
- Netherlands Organization for Scientific Research (NWO-ECHO)
- China Scholarship Council (CSC)
- Ministry of Education, Culture and Science [024.001.035]
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Catalytic enantioselective addition of organometallic nucleophiles to ketones is among the most straightforward approaches to the synthesis of chiral tertiary alcohols. The first such catalytic methodologies using the highly reactive organomagnesium reagents, which are the preferred organometallic reagents in terms of cost, availability, atom efficiency, and structural diversity, were developed only during the last five years. This Concept article highlights the fundamental breakthrough that made the development of methodologies for highly enantioselective Cu-I-catalyzed alkylation of ketones using organomagnesium reagents possible.
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