Journal
OPTICS LETTERS
Volume 41, Issue 7, Pages 1656-1659Publisher
OPTICAL SOC AMER
DOI: 10.1364/OL.41.001656
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Funding
- National Institutes of Health (NIH) [1R01EY017656-06, 1U01NS090438-01, 9P41EB015871-28, DP3DK101024-01, 1-R01HL121386-01, 1R21NS091982-01, 1U01CA202177-01]
- Hamamatsu Corporation
- Singapore-MIT Alliance for Research and Technology Centre (SMART)
- MIT SkolTech Initiative
- Koch Institute for Integrative Cancer Research Bridge Project Initiative
- Connecticut Children's Medical Center
- Samsung Advanced Institute of Technology
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Sensitivity of the amplitude and phase measurements in interferometric microscopy is influenced by factors such as instrument design and environmental interferences. Through development of a theoretical framework followed by experimental validation, we show photon shot noise is often the limiting factor in interferometric microscopy measurements. Thereafter, we demonstrate how a state-of-the-art camera with million-level electrons full well capacity can significantly reduce shot noise contribution resulting in a stability of optical path length down to a few picometers even in a near-common-path interferometer. (C) 2016 Optical Society of America
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