Journal
CHEMISTRY OF MATERIALS
Volume 27, Issue 2, Pages 483-496Publisher
AMER CHEMICAL SOC
DOI: 10.1021/cm503647k
Keywords
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Funding
- National Natural Science Foundation of China (NSFC) [21271053, 21401032, 51472058, 51332008]
- Research Fund for the Doctoral Program of Higher Education of China [20112304110021]
- Natural Science Foundation of Heilongjiang Province [B201403]
- Harbin Sci.-Tech. Innovation Foundation [2014RFQXJ019]
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To integrate photothermal therapy (PTT) with chemotherapy for improved antitumor efficiency, we designed a novel multifunctional composite by attaching CuxS nanoparticles onto the surface of Y2O3:Yb/Er hollow spheres through a combined coprecipitation and subsequent hydrothermal route. By altering the initial pH values for the synthesis of precursors, the size and structure properties of the final composites can controllably be tuned. The conjugated folic acid (FA) makes the composite recognize the targeted cancer cells and the attached CuxS nanoparticles endow the composite with photothermal function. It is found that the release of doxorubicin (DOX) from the functional carrier could be triggered by both pH value and near-infrared (NIR) radiation. In particular, both PTT and chemotherapy can be simultaneously driven by 980 nm laser irradiation. The synergistic therapeutic effect based on PTT and chemotherapy can lead to low in vitro viability of 12.9% and highly strong inhibition of animal H22 tumor in vivo, which is superior to any individual therapy. Moreover, the composite exhibits the clear in vivo red up-conversion luminescence (UCL). This multifunctional nanocarrier can be applicable as bioimaging agent and effective antitumor agent for the synergistic interaction between PTT and the enhanced chemotherapy.
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