CYP gene expressions in obesity-associated metabolic syndrome

Purpose: The contribution of cytochrome P450 (CYP) gene expressions in metabolic syndrome (MetS) has not been elucidated, and was the aim of this study. Methods: A total of 51 MetS patients and 41 healthy controls with similar age and sex were included to this study. mRNA from blood samples was extracted, and real-time polymerase chain reaction was performed for gene expressions using a dynamic array system. Results: We observed marked suppressions in CYP2A6 (p = 0.0123), CYP4F2 (p = 0.0005), CYP3A5 (p = 0.0003), and CYP17A1 (p < 0.0001) gene expressions in MetS patients. Conclusions: This is the first study to provide evidence that depressed expressions of CYP2A6, CYP4F2, CYP3A5, and CYP17A1 genes may play a role in MetS. (C) 2016 Asia Oceania Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved.