Journal
OBESITY FACTS
Volume 9, Issue 6, Pages 365-378Publisher
KARGER
DOI: 10.1159/000449507
Keywords
Berberine; Microbiota-gut-brain axis; Obesity; Gut hormones
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Funding
- National Natural Science Foundation of China [81270885, 81300653]
- Clinical Potential Subject Construction of Shanghai Jiaotong University School of Medicine
- Ministry of Science and Technology in China [201203524906]
- Science and Technology Commission of Shanghai Municipality [14495810700, 16410723200]
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Objective: To investigate whether or not berberine could improve metabolic status of high fat-fed rats through modulation of microbiota-gut-brain axis. Methods: Berberine was administered on high-fat-fed Sprague-Dawley rats. Brain-gut hormones were detected, and changes of gut microbiota were analyzed by 16S rRNA gene sequencing. Results: Berberine could reduce weight gain and lipolysis in the high-fat diet-fed group. Moreover, trends of ameliorated insulin resistance and decreased endogenous glucose production were observed. In addition, the microbiota-gut-brain axis was found to be modulated, including structural and diversity changes of microbiota, elevated serum glucagon-like peptide-land neuropeptide Y level, decreased orexin A level, up-regulated glucagon-like peptide-1 receptor mRNA level as well as ultra-structural improvement of the hypothalamus. Conclusion: Taken together, our findings suggest that berberine improved metabolic disorders induced by high-fat diet through modulation of the microbiota-gut-brain axis. (C) 2016 The Author(s) Published by Karger GmbH, Freiburg
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