4.3 Article

Ni(H)-Catalyzed Sulfonylation of ortho C-H Bonds in Aromatic Amides Utilizing an N,N-Bidentate Directing Group

Journal

CHEMISTRY LETTERS
Volume 44, Issue 7, Pages 902-904

Publisher

CHEMICAL SOC JAPAN
DOI: 10.1246/cl.150239

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Funding

  1. Monbusho (The Ministry of Education, Culture, Sports, Science and Technology)
  2. Japan Science and Technology Agency
  3. Grants-in-Aid for Scientific Research [15H02177] Funding Source: KAKEN

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The reaction of aromatic amides containing a 5-chloro-8-aminoquinoline moiety as the directing group with arylsulfonyl chlorides in the presence of Ni(OTf)(2) as the catalyst results in sulfonylation at the ortho-position. Various arylsulfonyl chlorides can be used as the coupling partners.

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