Journal
OBESITY
Volume 24, Issue 5, Pages 1097-1105Publisher
WILEY
DOI: 10.1002/oby.21467
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Funding
- Natural Science Foundation of China [81302420]
- Heilongjiang Province Study Abroad Returnees Science Fund [LC2015028]
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Objective: Obesity is primarily characterized by the accumulation of large amounts of fat in adipose tissue. Within the adipose tissue, adipocytes are derived from adipose tissue-derived stromal cells (ADSCs) via a specialized cell lineage differentiation process, and ADSCs play a key role in the generation and metabolism of adipose tissue. This study investigated whether microRNAs (miRNAs) play a role in adipocyte differentiation. Methods: Using luciferase reporter and ChIP assays, the relationship between miR-29b, SP1, and TNF-alpha was examined. Results: During the normal adipogenic differentiation of ADSCs, up-regulation of miR-29b promoted adipogenesis by enhancing SP1-mediated inhibition of TNF-alpha. Conclusions: This study investigated the regulatory role of miR-29b during the adipogenic differentiation of ADSCs and found that miR-29b is an effective positive regulator of adipogenesis.
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