Journal
NUTRITION JOURNAL
Volume 15, Issue -, Pages -Publisher
BMC
DOI: 10.1186/s12937-016-0213-6
Keywords
Blood serum lipid profile; L. fermentum ME-3; Oxidized LDL; HbA1c%; Human clinical trial
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Funding
- Estonian Ministry of Education and Research Institutional Research Funding [IUT20-42]
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Background: Cardiovascular diseases continue to be a challenge and burden to heath. The incidence of type 2 diabetes is increasing. Modifying the (common) risk factors of them is the key of longterm success. The aim of the study was to establish if the special composition of innovative food supplement Reg'Activ Cholesterol (RAC) has a positive influence to the human body cardiovascular-inflammatory and diabetic parameters. Methods: Forty-five clinically asymptomatic participants consumed an RAC containing an antioxidative and antiatherogenic probiotic Lactobacillus fermentum ME-3 (LFME-3) for 4 weeks. The parameters measured were total cholesterol, HDL cholesterol, LDL cholesterol, triglyceride, oxLDL, hsCRP, IL-6 and glycosylated haemoglobin (HbA1c%). Results: The cardiovascular and diabetes risk profile of the participants improved significantly after 4 weeks of the intervention. The reduction of total cholesterol (from 6.5 +/- 1.0 to 5.7 +/- 0.9 mmol/l, p = 9.90806E-11) was on the account of LDL cholesterol as the HDL cholesterol level rose from 1.60 +/- 0.31to 1.67 +/- 0.34mml/l, p = 0.01. HbA1c% was reduced from 5.85 +/- 0.28 to 5.66 +/- 0.25 p = 4.64E-05 and oxLDL decreased from 84 +/- 20 to 71 +/- 15 U/l, p = 4.66292E-08. Conclusions: The consumption of RAC in clinically asymptomatic volunteers with borderline-high values of risk factors for cardiovascular disease (BMI, HbA1c%, LDL cholesterol) for 4 weeks had a positive effect on blood lipoprotein, oxidative stress and inflammatory profile. There are no human trials published before with RAC.
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