Journal
NUTRITION
Volume 32, Issue 2, Pages 260-264Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.nut.2015.08.018
Keywords
Fruit; Heterocyclic amines; DNA damage; Risk of cancer; DNA adducts
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Funding
- Sao Paulo Research Foundation [procedural 2009/15831-0, 2012/10965-0, 2014/04607-0, 2014/16347-2]
- National Counsel of Technological and Scientific Development (CNPq) [procedural 481176/2008-0]
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Objective: To assess joint effects of heterocyclic amine (HCA), fruit, and vegetable intake on DNA damage in a general population. Methods: A cross-sectional survey (ISA-Capital) was performed among adults and older adults in Brazil. We selected 73 participants with high HCA intake and 73 sex- and age-matched participants with non-HCA intake (n = 146) for the present study. Diet was assessed by a 24-h dietary recall and a structured questionnaire with cooking methods and levels of meat doneness. DNA damage was measured by 8-oxo-2'-deoxyguanosine (8-OHdG). The association between DNA damage and dietary intake was analyzed by linear regression models. Results: Fruit intake showed significantly inverse association with 8-OHdG (beta, -0.787; P = 0.035), whereas HCA intake was significantly associated with increased DNA damage (beta, 1.621; P = 0.036) after adjusting for covariates, including sex, age, body mass index, energy intake, smoking, physical activity, and C-reactive protein. Vegetable intake was not significantly associated with 8-OHdG. We also found a significant association between joint fruit and HCA intake and DNA damage, and the difference in 8-OHdG levels was significantly higher between participants with the lowest fruit intake and highest HCA intake and those with the highest fruit intake and non-HCA intake (P = 0.049). Conclusions: Lower intake of fruits and higher intake of HCAs were associated with higher DNA damage levels and showed an additive effect pattern. (C) 2016 Elsevier Inc. All rights reserved.
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