Journal
NUCLEIC ACIDS RESEARCH
Volume 45, Issue D1, Pages D369-D379Publisher
OXFORD UNIV PRESS
DOI: 10.1093/nar/gkw1102
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Funding
- National Institutes of Health Office of Research Infrastructure Programs [R01OD010929, R24OD011194]
- National Institutes of Health National Heart, Lung and Blood Institute [U54HL117798]
- Genome Canada Largescale Applied Proteomics/Ontario Genomics Institute [OGI-069]
- Genome Quebec International Recruitment Award
- Canada Research Chair in Systems and Synthetic Biology
- National Institute of Health [R01OD010929]
- Biotechnology and Biological Sciences Research Council [BB/F010486/1] Funding Source: researchfish
- BBSRC [BB/F010486/1] Funding Source: UKRI
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The Biological General Repository for Interaction Datasets (BioGRID: https://thebiogrid.org) is an open access database dedicated to the annotation and archival of protein, genetic and chemical interactions for all major model organism species and humans. As of September 2016 (build 3.4.140), the BioGRID contains 1 072 173 genetic and protein interactions, and 38 559 post-translational modifications, as manually annotated from 48 114 publications. This dataset represents interaction records for 66 model organisms and represents a 30% increase compared to the previous 2015 BioGRID update. BioGRID curates the biomedical literature for major model organism species, including humans, with a recent emphasis on central biological processes and specific human diseases. To facilitate network-based approaches to drug discovery, BioGRID now incorporates 27 501 chemical-protein interactions for human drug targets, as drawn from the DrugBank database. A new dynamic interaction network viewer allows the easy navigation and filtering of all genetic and protein interaction data, as well as for bioactive compounds and their established targets. BioGRID data are directly downloadable without restriction in a variety of standardized formats and are freely distributed through partner model organism databases and meta-databases.
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